Yanık Sonrası Gelişen Bakteriyel Translokasyon Üzerine Amifostin’in (WR-2721) Etkisi

Objective: Disruption of the intestinal epithelial barrier has been shown to occur following burn injury. This process can lead translocation pathogens from gut lumen systemic circulation and distant organs thereby increasing risk for sepsis. The aim this study was examine effect amifostine (WR-2721) on bacterial in a rat injury model. Material Method: A total 27 male Wistar albino rats were divided into three groups nine. Group I control group. II III subjected third-degree burns over 30% body surface area, group administered 200 ml/kg intraperitoneally, followed by 10 ml/kg/day maintenance dose after undergoing burns. After 48 hours, tissue blood samples obtained cultured liver, spleen, mesenteric lymph nodes, cecum. Results: Blood cultures negative all groups. In group, colonization appeared only cecum, but III, found While most frequently cecum counts did not significantly differ (P = 0.298) nodes 0.418) between III. Conclusion: Amifostine alone is effective controlling associated with injuries. These results should be interpreted caution as there are number factors that affect translocation.